Unlock a rare development opportunity in the heart of Potrero Hill with this vacant duplex at 2109-2111 22nd Street. Perfectly positioned in one of San Francisco's most coveted neighborhoods, this property features two charming "mini-residences" offering immediate versatility: a light-filled top-floor unit with a private deck and a lower-level retreat leading to an expansive patio. Situated on a deep lot, the site serves as a blank canvas for a visionary expansion or a lush urban garden sanctuary. The location is a commuter's dream with seamless freeway access and close proximity to Zuckerberg San Francisco General, UCSF Mission Bay, and the convenience of Whole Foods just blocks away. Add this duplex to your portfolio and take advantage of city's current red hot rental market, or develop the property to maximize its potential in one of San Francisco's coolest neighborhoods Potrero Hill.

Based on information submitted to CRMLS as of May 21, 2026 4:20 AM EDT . All data is deemed reliable but is not guaranteed accurate by the MLS. All information should be independently reviewed and verified for accuracy. IDX information is provided exclusively for consumers’ personal, noncommercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing.

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